D55.21
✓ BillableAnemia due to pyruvate kinase deficiency
Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89)
Also Known As
❌ Excludes1
inheritedRules inherited from parent codes in the hierarchy.
Clinical Description
ICD-10-CM code D55.21 represents anemia due to pyruvate kinase deficiency. This code falls under the Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89) classification. It is a billable/specific code valid for HIPAA-covered transactions as of October 1, 2025 (FY2026). This code can be used to indicate a diagnosis for reimbursement purposes on insurance claims.
This is a 6-character code at the 5th level of specificity. This is the most specific code available in this subcategory. Coders should note that D55.21 has 2 Excludes1 restriction(s) — codes that cannot be reported together on the same claim.
Frequently Asked Questions
What is ICD-10 code D55.21?
ICD-10-CM code D55.21 is "Anemia due to pyruvate kinase deficiency". It belongs to the category: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89).
Is D55.21 a billable ICD-10 code?
Yes, D55.21 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
What codes are excluded with D55.21?
D55.21 has 2 Excludes1 rule(s). These codes are mutually exclusive and cannot be coded together on the same claim.
Related Codes in D55.2
Other codes in the same category that may be relevant for differential coding:
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Data Source
CMS ICD-10-CM 2026 Tabular List
Updated October 1, 2025 (FY2026)