D57.21
⚠ Non-billable (Header)Sickle-cell/Hb-C disease with crisis
Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89)
⚠️ This is a category header code — not billable. Use a more specific child code below.
✅ No additional coding notes for D57.21
Child Codes (6)
D57.211Sickle-cell/Hb-C disease with acute chest syndromeD57.212Sickle-cell/Hb-C disease with splenic sequestrationD57.213Sickle-cell/Hb-C disease with cerebral vascular involvementD57.214Sickle-cell/Hb-C disease with dactylitisD57.218Sickle-cell/Hb-C disease with crisis with other specified complicationD57.219Sickle-cell/Hb-C disease with crisis, unspecified
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CodeD57.21
BillableNo — Header code
ParentD57.2
CategoryDiseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89)
Excludes10 rule(s)
Excludes20 note(s)
Child codes6
Data Source
CMS ICD-10-CM 2026 Tabular List
Updated October 1, 2025 (FY2026)