E88.0
⚠ Non-billable (Header)Disorders of plasma-protein metabolism, not elsewhere classified
Endocrine, nutritional and metabolic diseases (E00-E89)
⚠️ This is a category header code — not billable. Use a more specific child code below.
❌ Excludes1
directThese codes are mutually exclusive. Never code them together.
- • monoclonal gammopathy (of undetermined significance) (D47.2)
- • polyclonal hypergammaglobulinemia (D89.0)
- • Waldenström macroglobulinemia (C88.00)
❌ Excludes1
inheritedRules inherited from parent codes in the hierarchy.
- • histiocytosis X (chronic) (C96.6)
⚠️ Excludes2
directBoth codes can exist if both conditions are documented.
- • disorder of lipoprotein metabolism (E78.-)
📋 Code Instructions
inherited- • codes for associated conditions
Child Codes (3)
Clinical Description
ICD-10-CM code E88.0 represents disorders of plasma-protein metabolism, not elsewhere classified. This code falls under the Endocrine, nutritional and metabolic diseases (E00-E89) classification. It is a non-billable category header code. A more specific child code from the list below must be used for billing and reimbursement purposes.
This is a 5-character code at the 4th level of specificity. There are 3 more specific child codes under E88.0. Coders should note that E88.0 has 4 Excludes1 restriction(s) — codes that cannot be reported together on the same claim.
Frequently Asked Questions
What is ICD-10 code E88.0?
ICD-10-CM code E88.0 is "Disorders of plasma-protein metabolism, not elsewhere classified". It belongs to the category: Endocrine, nutritional and metabolic diseases (E00-E89).
Is E88.0 a billable ICD-10 code?
No, E88.0 is a non-billable header code. A more specific child code must be used for billing.
What codes are excluded with E88.0?
E88.0 has 4 Excludes1 rule(s). These codes are mutually exclusive and cannot be coded together on the same claim.
Can E88.0 be coded with other codes?
E88.0 has 1 Excludes2 note(s). These conditions can be coded together if both are documented in the patient record.
Related Codes in E88
Other codes in the same category that may be relevant for differential coding:
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Data Source
CMS ICD-10-CM 2026 Tabular List
Updated October 1, 2025 (FY2026)