E88.12

✓ Billable

Generalized lipodystrophy

Endocrine, nutritional and metabolic diseases (E00-E89)

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Also Known As

Acquired generalized lipodystrophy (AGL)Berardinelli-Siep syndromeCongenital generalized lipodystrophy (CGL)Lawrence syndrome

❌ Excludes1

inherited

Rules inherited from parent codes in the hierarchy.

  • Whipple's disease (K90.81)
  • histiocytosis X (chronic) (C96.6)

📋 Code Instructions

inherited
  • codes for associated conditions

Clinical Description

ICD-10-CM code E88.12 represents generalized lipodystrophy. This code falls under the Endocrine, nutritional and metabolic diseases (E00-E89) classification. It is a billable/specific code valid for HIPAA-covered transactions as of October 1, 2025 (FY2026). This code can be used to indicate a diagnosis for reimbursement purposes on insurance claims.

This is a 6-character code at the 5th level of specificity. This is the most specific code available in this subcategory. Coders should note that E88.12 has 2 Excludes1 restriction(s) — codes that cannot be reported together on the same claim.

Frequently Asked Questions

What is ICD-10 code E88.12?

ICD-10-CM code E88.12 is "Generalized lipodystrophy". It belongs to the category: Endocrine, nutritional and metabolic diseases (E00-E89).

Is E88.12 a billable ICD-10 code?

Yes, E88.12 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.

What codes are excluded with E88.12?

E88.12 has 2 Excludes1 rule(s). These codes are mutually exclusive and cannot be coded together on the same claim.

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Code Information

CodeE88.12
BillableYes
ParentE88.1
CategoryEndocrine, nutritional and metabolic diseases (E00-E89)
Excludes12 rule(s)
Excludes20 note(s)

Data Source

CMS ICD-10-CM 2026 Tabular List

Updated October 1, 2025 (FY2026)