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R65.2

⚠ Non-billable (Header)

Severe sepsis

Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R99)

⚠️ This is a category header code — not billable. Use a more specific child code below.

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Also Known As

Infection with associated acute organ dysfunctionSepsis with acute organ dysfunctionSepsis with multiple organ dysfunctionSystemic inflammatory response syndrome due to infectious process with acute organ dysfunction

📋 Code Instructions

  • • code to identify specific acute organ dysfunction, such as:
  • • acute kidney failure (N17.-)
  • • acute respiratory failure (J96.0-)
  • • critical illness myopathy (G72.81)
  • • critical illness polyneuropathy (G62.81)
  • • disseminated intravascular coagulopathy [DIC] (D65)
  • • encephalopathy (metabolic) (septic) (G93.41)
  • • hepatic failure (K72.0-)
  • • Code first: underlying infection, such as:
  • • Code first: infection following a procedure (T81.4-)
  • • Code first: infections following infusion, transfusion and therapeutic injection (T80.2-)
  • • Code first: puerperal sepsis (O85)
  • • Code first: sepsis following complete or unspecified spontaneous abortion (O03.87)
  • • Code first: sepsis following ectopic and molar pregnancy (O08.82)
  • • Code first: sepsis following incomplete spontaneous abortion (O03.37)
  • • Code first: sepsis following (induced) termination of pregnancy (O04.87)
  • • Code first: sepsis NOS (A41.9)

Child Codes (2)

R65.20Severe sepsis without septic shockR65.21Severe sepsis with septic shock

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Code Information

CodeR65.2
BillableNo — Header code
ParentR65
CategorySymptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R99)
Excludes10 rule(s)
Excludes20 note(s)
Child codes2

Data Source

CMS ICD-10-CM 2026 Tabular List

Updated October 1, 2025 (FY2026)