D81
⚠ Non-billable (Header)Combined immunodeficiencies
Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89)
⚠️ This is a category header code — not billable. Use a more specific child code below.
❌ Excludes1
directCannot be coded with D81
- • autosomal recessive agammaglobulinemia (Swiss type) (D80.0)
Child Codes (10)
D81.0Severe combined immunodeficiency [SCID] with reticular dysgenesisD81.1Severe combined immunodeficiency [SCID] with low T- and B-cell numbersD81.2Severe combined immunodeficiency [SCID] with low or normal B-cell numbersD81.3Adenosine deaminase [ADA] deficiencyD81.4Nezelof's syndromeD81.5Purine nucleoside phosphorylase [PNP] deficiencyD81.6Major histocompatibility complex class I deficiencyD81.7Major histocompatibility complex class II deficiencyD81.8Other combined immunodeficienciesD81.9Combined immunodeficiency, unspecified
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CodeD81
BillableNo — Header code
CategoryDiseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89)
Excludes11 rule(s)
Excludes20 note(s)
Child codes10
Data Source
CMS ICD-10-CM 2026 Tabular List
Updated October 1, 2025 (FY2026)