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D81.5

✓ Billable

Purine nucleoside phosphorylase [PNP] deficiency

Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89)

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❌ Excludes1

inherited from D81

Rules from parent category D81: Combined immunodeficiencies

  • • autosomal recessive agammaglobulinemia (Swiss type) (D80.0)

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Code Information

CodeD81.5
BillableYes
ParentD81
CategoryDiseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89)
Excludes11 rule(s)
Excludes20 note(s)

Data Source

CMS ICD-10-CM 2026 Tabular List

Updated October 1, 2025 (FY2026)