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D89.3

✓ Billable

Immune reconstitution syndrome

Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89)

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Also Known As

Immune reconstitution inflammatory syndrome [IRIS]

📋 Code Instructions

  • • code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)

❌ Excludes1

inherited from D89

Rules from parent category D89: Other disorders involving the immune mechanism, not elsewhere classified

  • • hyperglobulinemia NOS (R77.1)
  • • monoclonal gammopathy (of undetermined significance) (D47.2)

⚠️ Excludes2

inherited from D89

Rules from parent category D89: Other disorders involving the immune mechanism, not elsewhere classified

  • • transplant failure and rejection (T86.-)

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Code Information

CodeD89.3
BillableYes
ParentD89
CategoryDiseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89)
Excludes12 rule(s)
Excludes21 note(s)

Data Source

CMS ICD-10-CM 2026 Tabular List

Updated October 1, 2025 (FY2026)