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E22

⚠ Non-billable (Header)

Hyperfunction of pituitary gland

Endocrine, nutritional and metabolic diseases (E00-E89)

⚠️ This is a category header code — not billable. Use a more specific child code below.

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❌ Excludes1

direct

Cannot be coded with E22

  • • Cushing's syndrome (E24.-)
  • • Nelson's syndrome (E24.1)
  • • overproduction of ACTH not associated with Cushing's disease (E27.0)
  • • overproduction of pituitary ACTH (E24.0)
  • • overproduction of thyroid-stimulating hormone (E05.8-)

Child Codes (5)

E22.0Acromegaly and pituitary gigantismE22.1HyperprolactinemiaE22.2Syndrome of inappropriate secretion of antidiuretic hormoneE22.8Other hyperfunction of pituitary glandE22.9Hyperfunction of pituitary gland, unspecified

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Code Information

CodeE22
BillableNo — Header code
CategoryEndocrine, nutritional and metabolic diseases (E00-E89)
Excludes15 rule(s)
Excludes20 note(s)
Child codes5

Data Source

CMS ICD-10-CM 2026 Tabular List

Updated October 1, 2025 (FY2026)