E22.1
✓ BillableHyperprolactinemia
Endocrine, nutritional and metabolic diseases (E00-E89)
❌ Excludes1
inheritedRules inherited from parent codes in the hierarchy.
- • Cushing's syndrome (E24.-)
- • Nelson's syndrome (E24.1)
- • overproduction of ACTH not associated with Cushing's disease (E27.0)
- • overproduction of pituitary ACTH (E24.0)
- • overproduction of thyroid-stimulating hormone (E05.8-)
📋 Code Instructions
direct- • code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)
Clinical Description
ICD-10-CM code E22.1 represents hyperprolactinemia. This code falls under the Endocrine, nutritional and metabolic diseases (E00-E89) classification. It is a billable/specific code valid for HIPAA-covered transactions as of October 1, 2025 (FY2026). This code can be used to indicate a diagnosis for reimbursement purposes on insurance claims.
This is a 5-character code at the 4th level of specificity. This is the most specific code available in this subcategory. Coders should note that E22.1 has 5 Excludes1 restriction(s) — codes that cannot be reported together on the same claim.
Frequently Asked Questions
What is ICD-10 code E22.1?
ICD-10-CM code E22.1 is "Hyperprolactinemia". It belongs to the category: Endocrine, nutritional and metabolic diseases (E00-E89).
Is E22.1 a billable ICD-10 code?
Yes, E22.1 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
What codes are excluded with E22.1?
E22.1 has 5 Excludes1 rule(s). These codes are mutually exclusive and cannot be coded together on the same claim.
Related Codes in E22
Other codes in the same category that may be relevant for differential coding:
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Data Source
CMS ICD-10-CM 2026 Tabular List
Updated October 1, 2025 (FY2026)