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R65.1

⚠ Non-billable (Header)

Systemic inflammatory response syndrome (SIRS) of non-infectious origin

Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R99)

⚠️ This is a category header code — not billable. Use a more specific child code below.

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📋 Code Instructions

  • • Code first: underlying condition, such as:
  • • Code first: heatstroke (T67.0-)
  • • Code first: injury and trauma (S00-T88)

❌ Excludes1

direct

Cannot be coded with R65.1

  • • sepsis- code to infection
  • • severe sepsis (R65.2)

Child Codes (2)

R65.10Systemic inflammatory response syndrome (SIRS) of non-infectious origin without acute organ dysfunctionR65.11Systemic inflammatory response syndrome (SIRS) of non-infectious origin with acute organ dysfunction

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Code Information

CodeR65.1
BillableNo — Header code
ParentR65
CategorySymptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R99)
Excludes12 rule(s)
Excludes20 note(s)
Child codes2

Data Source

CMS ICD-10-CM 2026 Tabular List

Updated October 1, 2025 (FY2026)