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R65.11

✓ Billable

Systemic inflammatory response syndrome (SIRS) of non-infectious origin with acute organ dysfunction

Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R99)

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📋 Code Instructions

  • • code to identify specific acute organ dysfunction, such as:
  • • acute kidney failure (N17.-)
  • • acute respiratory failure (J96.0-)
  • • critical illness myopathy (G72.81)
  • • critical illness polyneuropathy (G62.81)
  • • disseminated intravascular coagulopathy [DIC] (D65)
  • • encephalopathy (metabolic) (septic) (G93.41)
  • • hepatic failure (K72.0-)

❌ Excludes1

inherited from R65.1

Rules from parent category R65.1: Systemic inflammatory response syndrome (SIRS) of non-infectious origin

  • • sepsis- code to infection
  • • severe sepsis (R65.2)

📋 Code Instructions

from R65.1
  • • Code first: underlying condition, such as:
  • • Code first: heatstroke (T67.0-)
  • • Code first: injury and trauma (S00-T88)

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Code Information

CodeR65.11
BillableYes
ParentR65.1
CategorySymptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R99)
Excludes12 rule(s)
Excludes20 note(s)

Data Source

CMS ICD-10-CM 2026 Tabular List

Updated October 1, 2025 (FY2026)