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D81.81

⚠ Non-billable (Header)

Biotin-dependent carboxylase deficiency

Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89)

⚠️ This is a category header code — not billable. Use a more specific child code below.

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Also Known As

Multiple carboxylase deficiency

❌ Excludes1

direct

Cannot be coded with D81.81

  • • biotin-dependent carboxylase deficiency due to dietary deficiency of biotin (E53.8)

Child Codes (3)

D81.810Biotinidase deficiencyD81.818Other biotin-dependent carboxylase deficiencyD81.819Biotin-dependent carboxylase deficiency, unspecified

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Code Information

CodeD81.81
BillableNo — Header code
ParentD81.8
CategoryDiseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89)
Excludes11 rule(s)
Excludes20 note(s)
Child codes3

Data Source

CMS ICD-10-CM 2026 Tabular List

Updated October 1, 2025 (FY2026)