D57.45
⚠ Non-billable (Header)Sickle-cell thalassemia beta plus with crisis
Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89)
⚠️ This is a category header code — not billable. Use a more specific child code below.
Also Known As
HbS-beta plus with crisisSickle-cell beta plus with crisis
✅ No additional coding notes for D57.45
Child Codes (6)
D57.451Sickle-cell thalassemia beta plus with acute chest syndromeD57.452Sickle-cell thalassemia beta plus with splenic sequestrationD57.453Sickle-cell thalassemia beta plus with cerebral vascular involvementD57.454Sickle-cell thalassemia beta plus with dactylitisD57.458Sickle-cell thalassemia beta plus with crisis with other specified complicationD57.459Sickle-cell thalassemia beta plus with crisis, unspecified
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CodeD57.45
BillableNo — Header code
ParentD57.4
CategoryDiseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89)
Excludes10 rule(s)
Excludes20 note(s)
Child codes6
Data Source
CMS ICD-10-CM 2026 Tabular List
Updated October 1, 2025 (FY2026)